Aqueous extract of bitter leaf Vernonia amygdalina Delile (Asterales: Asteraceae) ameliorates testosterone-induced benign prostatic hyperplasia (BPH) in Wistar rats
| Autor: | John Oluwagbenga Balogun, G. O. Alege, Abayomi Ajayi, Titilayo Ige, Ekanem Ikanna Asuquo, Akpovughaye Taiga, Nich Arawa Ude, O Omotoso |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aqueous extract biology Traditional medicine 010405 organic chemistry Vernonia amygdalina Testosterone (patch) Asteraceae biology.organism_classification medicine.disease 01 natural sciences 0104 chemical sciences 03 medical and health sciences 030104 developmental biology Asterales Botany medicine General Earth and Planetary Sciences Benign prostatic hyperplasia (BPH) General Environmental Science |
| Zdroj: | Brazilian Journal of Biological Sciences. 4:45-52 |
| ISSN: | 2358-2731 |
| Popis: | Benign prostatic hyperplasia (BPH) is an age-dependent condition involving prostate enlargement which may lead to lower urinary tract symptoms (LUTS). This study was designed to study the ameliorative effect of the aqueous extract of bitter leaf Vernonia amygdalina Delile (Asterales: Asteraceae) on testosterone-induced BPH in a rat model. Thirty adult male Wister rats were randomly divided into six groups (A to F), with BPH induced through a single subcutaneous injection of 5 mg/kg of testosterone propionate (TP) and Vernonia amygdalina administered in various doses through oral gavage for 14 days. Group A (control) was administered with distilled water only, group B with 5 mg/kg of TP only, group C with 5 g/mL of V. amygdalina only, group D with 5 mg/kg of TP and 5 g/mL of V. amygdalina, group E with 5 mg/kg of TP and 7.5 g/mL of V. amygdalina and group F with 5 mg/kg of TP and 10 g/ml of V. amygdalina. Results show that testosterone caused histological changes that are similar to the presentation of BPH in the prostate. Aqueous extract of V. amygdalina was observed to ameliorate testosterone-induced histological changes and prostatic parameters especially at higher concentration. This suggests that bitter leaf could be a candidate herb for the treatment of BPH. |
| Databáze: | OpenAIRE |
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