Erythropoietin-induced DNA synthesis in normoblasts : Effect of actinomycin-D

Autor:	L. Berman, E. Powsner
Rok vydání:	1967
Předmět:	Dactinomycin DNA synthesis Stimulation General Medicine Biology Molecular biology General Biochemistry Genetics and Molecular Biology In vitro chemistry.chemical_compound chemistry Erythropoietin medicine General Pharmacology Toxicology and Pharmaceutics Thymidine Heme DNA medicine.drug
Zdroj:	Life Sciences. 6:1713-1722
ISSN:	0024-3205
DOI:	10.1016/0024-3205(67)90140-3
Popis:	Erythropoietin stimulates DNA and heme synthesis by erythroblasts in vitro . Actinomycin-D completely suppresses the ESF stimulation of heme synthesis without affecting heme synthesis in control cultures. At the same concentration, AM depresses DNA synthesis in both ESF and control cultures but does not abolish the stimulation of DNA synthesis by ESF. We conclude that the ESF stimulation of DNA synthesis is not dependent on the stimulation of heme synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8b1789bfb505f25f444475c700534ddd https://doi.org/10.1016/0024-3205(67)90140-3 Zobrazit plný text záznamu