Novel and facile methods for the synthesis of DTPA-mono-amide: a new completely revised strategy in radiopharmaceutical chemistry
| Autor: | Seyed Esmaeil Sadat Ebrahimi, Amirreza Hosseinzadeh, Elham Hashemi, Massoud Amanlou, Mohammad Hossein Babaei, Mona Mosayebnia, Mehdi Shafiee Ardestani, Mohammad Shafiee-Alavidjeh, Ali Jabbari Arabzadeh, Zahra Heidari, Hamidreza Ebrahimi, Arman Rahmim, Abbas Alavi |
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| Rok vydání: | 2009 |
| Předmět: |
Green chemistry
Curium organic chemicals animal diseases Health Toxicology and Mutagenesis Inorganic chemistry Public Health Environmental and Occupational Health chemistry.chemical_element Americium respiratory system Pollution Combinatorial chemistry Metal Chelator Analytical Chemistry chemistry.chemical_compound Nuclear Energy and Engineering chemistry Yield (chemistry) Amide cardiovascular system Radiology Nuclear Medicine and imaging Chelation Spectroscopy circulatory and respiratory physiology Conjugate |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 283:447-455 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-009-0414-y |
| Popis: | DTPA is a very strong metal chelator widely utilized in radiopharmaceutical chemistry for conjugation of chemicals which do not have enough potency for direct metalo-labeling and also to manage toxic radioactive materials such as plutonium, americium, and curium. It is difficult to conjugate DTPA to an amine group in a singular direction and such reactions usually also coincidently produce a mixture of DTPA-bis-amides and DTPA-mono-amide resulting in considerable insufficiencies/difficulties in synthesis and especially yield/separation procedures. In this paper, novel methods for the exclusive synthesis of DTPA-mono-amide have been established which extensively reduce the difficulties otherwise encountered and increase the reaction’s yield considering the green chemistry approaches. This is expected to be of interest to radiopharmaceutical researchers interested in the DTPA (Radio)-metallic-conjugate. Overall, this paper provides a framework to achieve a higher degree of propriety from DTPA as a chelator to conjugate to the chemical compounds. |
| Databáze: | OpenAIRE |
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