The model of resting forms of micobacteria for testing of chemodrugs for latent forms of tuberculosis

Autor:	O. I. Demidenok, A. M. Anuchin, Yu. K. Kudykina, Andrey L. Mulyukin, A. V. Goncharenko, Arseny S. Kaprelyants, M. M. Moisenovich, I. V. Galon
Rok vydání:	2010
Předmět:	Heat processing Tuberculosis biology Latent tuberculosis medicine.drug_class Mycobacterium smegmatis Antibiotics medicine.disease biology.organism_classification Applied Microbiology and Biotechnology Biochemistry Microbiology Rest state medicine Metabolic activity
Zdroj:	Applied Biochemistry and Microbiology. 46:282-288
ISSN:	1608-3024 0003-6838
DOI:	10.1134/s0003683810030063
Popis:	The new model of obtaining of ovoid resting forms Mycobacterium smegmatis, which are morphologically different from vegetative (rod-like) cells, was developed. Ovoid forms were characterized by a drastically decreased level of metabolic activity, an increased stability to heat processing and antibiotics action, and also by prolonged (more than 2 months) storage time preserving colony-forming ability. Obtained resting forms of mycobacteria may be used in test-systems for checking efficiency of new medical agents against latent forms of tuberculosis and determination of role of these of those genes in entering rest state.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8b0938dbc8ba4f25cbbd9912aba3dfbc https://doi.org/10.1134/s0003683810030063 Zobrazit plný text záznamu Plný text ve formátu PDF