Factors Predicting Mortality in Hospitalised Hiv-Negative Children with Lower-Chest-Wall Indrawing Pneumonia and Implications for Management
| Autor: | Oluyinka E. Olutunde, Bernard E. Ebruke, Samba O. Sow, Vicky L Baillie, Phil Seidenberg, Alice Kamau, Stephen R. C. Howie, Orin S. Levine, Christine Prosperi, Henry C. Baggett, Somsak Thamthitiwat, Donald M. Thea, Katherine L. O’Brien, David R. Murdoch, Nicholas S. S. Fancourt, Julia Rhodes, Lawrence Mwananyanda, Daniel R. Feikin, W. Abdullah Brooks, Juliet O. Awori, Shabir Ahmed Madhi, Milagritos D. Tapia, David P. Moore, Melissa M. Higdon, Katherine E. Gallagher, Maria Deloria Knoll, Karen L. Kotloff, Anthony Scott, Laura L. Hammitt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
History
Pediatrics medicine.medical_specialty Polymers and Plastics business.industry HIV exposure Human immunodeficiency virus (HIV) medicine.disease Lower chest wall Logistic regression medicine.disease_cause Industrial and Manufacturing Engineering Pneumonia Childhood pneumonia Weight for Age medicine Etiology Business and International Management business |
| Zdroj: | SSRN Electronic Journal. |
| ISSN: | 1556-5068 |
| DOI: | 10.2139/ssrn.3899796 |
| Popis: | Background: In 2013 the World Health Organization revised treatment guidelines for childhood pneumonia with lower chest wall indrawing (LCWI) to recommend home-based treatment rather than hospital admission. We analysed data from children hospitalized with LCWI pneumonia in the Pneumonia Etiology Research for Child Health (PERCH) study to identify sub-groups with high odds of mortality, who might continue to benefit from hospital management. Methods: PERCH enrolled 2189 HIV-negative children aged 2-59 months who were admitted to hospital with LCWI pneumonia between 2011-2014 in Kenya, Zambia, South Africa, Mali, The Gambia, Bangladesh, and Thailand. We analysed risk factors for mortality among these cases using logistic regression. Findings: Among 2189 cases with LCWI pneumonia, 76 (3·6%) died. Mortality was higher in infants compared to children 12-59 months of age (OR 2·03, 95%CI 1·05-3·93), in children with oxygen saturation |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|