Effect of thyroxine on glutathione-dependent antioxidant enzyme activities and glutathione content in the interscapular brown adipose tissue of different maturated rats

Autor:	P Dusko Blagojevic, L Aleksandra Nikolic, M Vojislav Petrovic, S Zorica Saicic, N Dejan Mijalkovic, B Mihajlo Spasic
Rok vydání:	2004
Předmět:	chemistry.chemical_classification medicine.medical_specialty Antioxidant medicine.medical_treatment Clinical Biochemistry Metabolism Glutathione chemistry.chemical_compound Enzyme medicine.anatomical_structure Endocrinology chemistry Internal medicine Brown adipose tissue medicine
Zdroj:	Jugoslovenska medicinska biohemija. 23:367-373
ISSN:	1452-8193 0354-3447
Popis:	Effect of thyroxine on glutathione-dependent antioxidant enzyme activities and glutathione (GSH) content in the interscapular brown adipose tissue (IBAT) of different aged rats were studied. Male Mill Hill hybrid hooded rats aged 15, 45 and 75 days were treated with L-thyroxine, T4 (40 mg/100 g body mass), s.c., one dose per day, 14 days (finally aged 30, 60 and 90 days, respectively). Effect of T4 on GSH-dependent antioxidant enzyme activities in the IBAT differs with respect to age. T4 treatment gradually decrease activities of all GSH-dependent antioxidant enzymes in 60 and 90 days old rats in comparison to young ones. GSH content in animals of 30 and 60 days old rats are lower in comparison with 90 days old rats, but the effects are oppposite. L-thyroxine treatment significantly increase GSH content in 30 days old rats (p
Databáze:	OpenAIRE
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