Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent

Autor:	Sangku Lee, Dong-Ho Choung, Ji Hye Min, Eun Ju Yun, Hyeong Kyu Lee, Kab Seog Yoon
Rok vydání:	2012
Předmět:	chemistry.chemical_compound chemistry In vivo Stereochemistry Aryl Organic Chemistry Cancer cell Moiety Isoxazole Combinatorial chemistry
Zdroj:	Synthetic Communications. 42:1890-1894
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397911.2010.546551
Popis:	A diaryl isoxazole compound, KRIBB3, which exhibits strong antimigratory and antimitotic activities against cancer cells, was prepared in a practical synthetic way. The synthetic method may provide easy access to KRIBB3 analogs with various substituents at an aryl moiety for structure–activity relationships (SAR), as well as a large quantity of KRIBB3 for in vivo studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8b02970ebe8c5dcd2440c9d31c58586f https://doi.org/10.1080/00397911.2010.546551 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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