Heterocyclic Resveratrol Analogs. Synthesis and Physiological Activity: Part 1–Analogs Obtained by the Replacement of Aryl Residues with Heterocyclic Fragments
| Autor: | Olga I. Balakireva, Elena V. Semenova, Alexander V. Semenov |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Antioxidant 010405 organic chemistry Phytoalexin Aryl medicine.medical_treatment Organic Chemistry food and beverages Biological activity Resveratrol 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Stilbene derivative Polyphenol medicine Bioorganic chemistry |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 47:134-148 |
| ISSN: | 1608-330X 1068-1620 |
| Popis: | Resveratrol is a polyphenolic phytoalexin, a stilbene derivative, whose physiological activities have been studied in a large number of studies. It demonstrated antioxidant, antitumor, neuroprotective, anti-inflammatory, antibacterial, and antiviral properties. In the last decade, much attention was paid to the development of resveratrol derivatives with the goal of improving its pharmacological profile and pharmacokinetics. Part 1 of the review is devoted to resveratrol synthetic analogs obtained by the replacement one or two phenyl moieties of the stilbene backbone with bioisosteric heterocyclic fragments. Attention was focused on the methods of synthesis of resveratrol analogs and their biological activity. |
| Databáze: | OpenAIRE |
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