Replication of Genetic Markers Associated with Clozapine-Induced Agranulocytosis

Autor:	Michael Lachowicz, Maria Athanasiou, Anil K. Malhotra, Igor Mosyagin, John M. Kane, Stanton L. Gerson, Ingolf Cascorbi, Michael Dettling, Carol R. Reed, Brad Dain
Rok vydání:	2006
Předmět:	Candidate gene HLA-DQB1 Side effect business.industry Immunology Cell Biology Hematology medicine.disease Bioinformatics Biochemistry Monitoring program Schizophrenia Cohort Medicine business Adverse effect Clozapine medicine.drug
Zdroj:	Blood. 108:1280-1280
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v108.11.1280.1280
Popis:	Clozapine is a highly efficacious drug for the treatment of schizophrenia, but its use is limited, in part due to the side effect of agranulocytosis. In order to reduce the incidence of clozapine-induced agranulocytosis (CIA), patients are required to submit to a blood monitoring program. A genetic component to CIA is suggested by published associations in a number of genes. A genetic test assessing the risk of CIA might allow safer and more broad use of clozapine. We previously conducted a candidate gene-based case-control study to discover genes associated with CIA. Cases were patients with an ANC A replication analysis was performed on an independently collected cohort of 49 cases and 78 controls from Germany. Cases were patients who developed an ANC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8aedf1c8be4c80a0c33dc935e825de59 https://doi.org/10.1182/blood.v108.11.1280.1280 Zobrazit plný text záznamu