Efficient Continuous-Flow Synthesis and Evaluation of Anticancer Activity of Novel Quinoline–Pyrazoline Derivatives

Autor:	K. Sunanda, V. Siddaiah, J. D. Lilakar, K. Santhosh Kumar, Aurobind Ganesh
Rok vydání:	2020
Předmět:	Phenyl hydrazine 010405 organic chemistry Chemistry Continuous flow Organic Chemistry Quinoline Pyrazoline derivatives Mass spectrometry 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound 13c nmr spectroscopy medicine Doxorubicin medicine.drug
Zdroj:	Russian Journal of Organic Chemistry. 56:2014-2021
ISSN:	1608-3393 1070-4280
Popis:	An efficient and simple continuous-flow synthetic protocol for novel quinoline-tethered pyrazoline derivatives, which involves condensation of 2-chloroquinoline-3-carbaldehydewith arylmethyl ketones followed by cyclisation with phenyl hydrazine, was developed. The newly synthesized pyrazolines were characterized by IR, 1H and 13C NMR spectroscopy, mass spectrometry, and elemental analysis and tested for anticancer activity against A375 (melanoma), MCF7 (breast), and HT-29 (colon) cell lines. Some of the newly synthesized derivatives showed a higher activity than the control drug Doxorubicin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8aeab83f4fd11cb8ff8796712dc6ce5c https://doi.org/10.1134/s1070428020110160 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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