Synthesis and characterization of amphiphilic block copolymer of polyphosphoester and poly(L-lactic acid)

Autor:	Hai Xia, Xianzhu Yang, Jun Wang, Yucai Wang, Ling-Yan Tang
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Polymers and Plastics Biocompatibility Chemistry Organic Chemistry Polymer Micelle Biodegradable polymer Polyester Polymer chemistry Amphiphile Materials Chemistry Copolymer Drug carrier
Zdroj:	Journal of Polymer Science Part A: Polymer Chemistry. 46:6425-6434
ISSN:	1099-0518 0887-624X
Popis:	Aliphatic polyesters and polyphosphoesters (PPEs) have received much interest in medical applications due to their favorable biocompatibility and biodegradability. In this work, novel amphiphilic triblock copolymers of PPE and poly(L-lactic acid) (PLLA) with various compositions were synthesized and characterized. The blocky structure was confirmed by GPC analyses. These triblock copolymers formed micelles composed of hydrophobic PLLA core and hydrophilic PPE shell in aqueous solution. Critical micellization concentrations of these triblock copolymers were related to the polymer compositions. Incubation of micelles at neutral pH followed by GPC analyses revealed that these polymer micelles were hydrolysized and resulted in decreased molecular weights and small oligomers, whereas its degradation in basic and acid mediums was accelerated. MTT assay also demonstrated the biocompatibility against HEK293 cells. These biodegradable polymers are potential as drug carriers for biomedical application.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8aea71d981b559fc04f1dc1028212a65 https://doi.org/10.1002/pola.22951 Zobrazit plný text záznamu Plný text