Zhuanggu Jianxi Decoction (壮骨健膝方) limits interleukin-1 β-induced degeneration chondrocytes via the caveolin-p38 MAPK signal pathway
| Autor: | Bao-jun Chen, Hu Yan, Xue-yi Lin, Wenting Wang, Ziyi Zhang, Meili Lu, Lu Sheng, Qing Zhang, Yiru Wang, Yanan Li, Su Youxin, Zhen He |
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| Rok vydání: | 2014 |
| Předmět: |
MAPK/ERK pathway
medicine.medical_specialty Chemistry p38 mitogen-activated protein kinases Decoction General Medicine Degeneration (medical) Zhuanggu jianxi Cell biology Blot Endocrinology Complementary and alternative medicine Internal medicine Caveolin medicine Pharmacology (medical) Protein kinase A |
| Zdroj: | Chinese Journal of Integrative Medicine. 20:353-359 |
| ISSN: | 1993-0402 1672-0415 |
| DOI: | 10.1007/s11655-014-1801-y |
| Popis: | Objective To evaluate the effect of Zhuanggu Jianxi Decoction (壮骨健膝方, ZGJXD) on interleukin-1 β (IL-1 β)-induced degeneration of chondrocytes (CDs) as well as the activation of caveolin-p38 mitogen-activated protein kinase (MAPK) signal pathway, investigating the possible molecular mechanism that ZGJXD treats osteoarthritis. |
| Databáze: | OpenAIRE |
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