Motion and twisting of magnetic particles ingested by alveolar macrophages in non-smokers and smokers: Implementation of viscoelasticity
| Autor: | Martin Kohlhäufl, Karl Häussinger, Wolfgang G. Kreyling, Kathrin Felten, Winfried Möller |
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| Rok vydání: | 2007 |
| Předmět: |
animal structures
Materials science Physics::Medical Physics equipment and supplies Condensed Matter Physics Viscoelasticity Quantitative Biology::Cell Behavior Electronic Optical and Magnetic Materials Physics::Fluid Dynamics Quantitative Biology::Subcellular Processes Viscosity Nuclear magnetic resonance Ferrimagnetism Biophysics Particle Magnetic nanoparticles Relaxation (physics) Cytoskeleton Magnetosphere particle motion |
| Zdroj: | Journal of Magnetism and Magnetic Materials. 311:269-274 |
| ISSN: | 0304-8853 |
| DOI: | 10.1016/j.jmmm.2006.10.1177 |
| Popis: | Ferrimagnetic iron oxide particles were inhaled by 17 healthy volunteers (9 non-smokers, 8 smokers), and the retained particles were magnetized and detected by a SQUID. Stochastic particle transport due to cytoskeletal reorganizations within macrophages (relaxation) and directed particle motion in a weak magnetic twisting field were investigated with respect to viscous and elastic properties of the cytoskeleton. Relaxation and cytoskeletal stiffness were not influenced by cigarette smoking. Relaxation and particle twisting revealed a non-Newtonian viscosity with a pure viscous and a viscoelastic compartment. Viscous and elastic data obtained from relaxation correlated with particle twisting, indicating that the proposed simple model is a reasonable approximation of cytoskeletal mechanical properties. |
| Databáze: | OpenAIRE |
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