Studies on Cataractogenesis in Humans and in Rats with Alloxan-Induced Diabetes
| Autor: | M. Ataur Rahman, Shahbaaz Ahmad, Stephanie Ahmad, K.C. Tsou |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Aldose reductase Hexokinase genetic structures Sorbitol dehydrogenase Dehydrogenase General Medicine Biology medicine.disease eye diseases Sensory Systems Cellular and Molecular Neuroscience Ophthalmology chemistry.chemical_compound Endocrinology Enzyme Biochemistry chemistry Internal medicine Diabetes mellitus Alloxan medicine Glucose-6-phosphate dehydrogenase sense organs |
| Zdroj: | Ophthalmic Research. 17:12-20 |
| ISSN: | 1423-0259 0030-3747 |
| DOI: | 10.1159/000265344 |
| Popis: | The effect of cataractogenesis on the behavior of some enzymes involved in glucose metabolism was examined histochemically both in human lenses and in rat lenses from rats with alloxan-induced diabetes. Several modifications in the currently available techniques were made in order to localize glucose-6-phosphate dehydrogenase, aldose reductase, sorbitol dehydrogenase, hexokinase and ketohexokinase in ocular lens. Human cataractous lenses showed a precipitous drop in glucose-6-phosphate dehydrogenase activity, whereas the lenticular tissues of alloxan-treated rats showed a gradual decrease of this enzyme with the prolongation of diabetes. Aldose reductase activity increased in hypermature and senile diabetic cataracts, whereas sorbitol dehydrogenase activity decreased in these lenses. Similarly, in alloxan-diabetic rat lenses the activity of aldose reductase increased while that of sorbitol dehydrogenase decreased with the prolongation of diabetes. Attempts were made to localize hexokinase and ketohexokinase in ocular lens. |
| Databáze: | OpenAIRE |
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