Two new flavonols from flowers of Getonia floribunda Roxb
| Autor: | Kwanjai Kanokmedhakul, Patcharee Chanhan, Kultida Suttaratrungse, Somdej Kanokmedhakul, Panawan Moosophon |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Traditional medicine Chemistry Stereochemistry Ms analysis Plant Science Getonia floribunda Oral cavity Biochemistry chemistry.chemical_compound Flavonols Phytochemical Pachypodol Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology |
| Zdroj: | Phytochemistry Letters. 11:316-319 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2015.02.004 |
| Popis: | Phytochemical investigation of the EtOAc and MeOH extracts from flowers of Getonia floribunda Roxb., a Thai herbal medicine, resulted in the isolation of two new flavonols, 4′-hydroxy-6,7,8,3′-tetramethoxyflavonol (1) and 4′-hydroxy-6,7,8-trimethoxyflavonol (2), along with a known pachypodol (3). Their structures were elucidated by spectroscopic methods including UV, IR, 1D and 2D NMR techniques and MS analysis. Compound 1 showed cytotoxicity against the oral cavity cancer (KB) cell line with an IC50 value of 8.99 ± 2.00 μg/ml. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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