Increased Levels of Circulating CD4+CD25+ T cells (T-regs) Correlate with Clinical Cancer Stage And Inversely Correlate with CD8+ T cell Frequency (49.18)
| Autor: | Amir Al-Khami, Alberto J. Montero, Mohamed L. Salem, Kristi Vissage, David J. Cole, C. Marcela Diaz-Montero |
|---|---|
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 178:S86-S86 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.178.supp.49.18 |
| Popis: | Regulatory T cells inhibit immune responses mediated by T cells. Increased circulating levels of T-regs in patients (pts) have been reported in some solid tumors. Moreover, increased apoptosis among circulating CD8+ T cells has been reported in cancer pts. The goal of our study was therefore to determine how levels of circulating T-regs and CD8+T cells correlate with clinical cancer stage in a diverse cohort of pts. Flow cytometry analyses were performed on whole blood from 14 normal healthy controls and 35 cancer pts with newly diagnosed tumors prior to any therapy (stages: I/II, n=12; III/IV n=23). Although no significant difference was observed in T-regs between normal and stage I/II cancer pts (4.36% vs. 4.92%), levels were significantly increased in stage III/IV pts (7.26%; p=0.039). Moreover, there was an inverse correlation between CD8+T cell frequencies and clinical cancer stage, with stage III/IV pts having the lowest levels relative to normal (3.97% vs. 7.01%; p=0.036). In conclusion, T-regs were increased only in pts with advanced stage III/IV cancer and percentage of total CD8+T cells inversely correlated with clinical tumor stage. Thus, increased levels of T-regs and decreased levels of CD8+ T cells might contribute to cancer-mediated immunosupression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|