Defining the Biology-Materials Interface using both 2D and 3D Lithography

Autor:	Wageesha Senaratne, James N. Turner, Christopher K. Ober, Matthew R. Hynd, Shalin J. Jhaveri, Prabuddha Sengupta, Shain Willia
Rok vydání:	2006
Předmět:	Materials science Polymers and Plastics Silicon Organic Chemistry technology industry and agriculture chemistry.chemical_element Nanotechnology Methacrylate chemistry Self-healing hydrogels Materials Chemistry Biosensor Lithography Electron-beam lithography
Zdroj:	Journal of Photopolymer Science and Technology. 19:435-440
ISSN:	1349-6336 0914-9244
Popis:	Two- and three-dimensional lithographic strategies were used to fabricate materials which enable control and study of biological processes with high efficiency. Electron-beam lithography was used to produce 2D patterns of micrometer-sized features of gold on silicon where dinitrophenyl end-capped ligand self-assembled monolayers were specifically immobilized to enable study of their interactions with specific receptors on mast cells. Two-photon lithography was used to produce 3D constructs of 2-hydroxyethyl methacrylate-based hydrogels on microfabricated silicon neural prosthetic devices. The hydrogels were used to deliver neurotrophins to stimulate neuronal cells in order to promote neuron stability and to make highly efficient connections between device electrodes and neurons. Both these lithographic strategies and their application demonstrate the influence of chemistry and topography of materials surfaces on cellular responses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8ac4c49957ad98b90d8a2f60e06cc5dc https://doi.org/10.2494/photopolymer.19.435 Zobrazit plný text záznamu