Fetal Programming: Prenatal Androgen Disrupts Positive Feedback Actions of Estradiol but Does Not Affect Timing of Puberty in Female Sheep1
| Autor: | Rachel A. Birch, Wen Ye, Carol Herkimer, Christine West, Jane E. Robinson, Tejinder Pal Sharma, Vasantha Padmanabhan, Douglas L. Foster |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Testosterone propionate
Estrous cycle medicine.medical_specialty medicine.drug_class Cell Biology General Medicine Biology Androgen chemistry.chemical_compound Follicle-stimulating hormone Endocrinology Reproductive Medicine chemistry Internal medicine medicine Gestation medicine.symptom Gonadotropin Luteinizing hormone Weight gain |
| Zdroj: | Biology of Reproduction. 66:924-933 |
| ISSN: | 1529-7268 0006-3363 |
| DOI: | 10.1095/biolreprod66.4.924 |
| Popis: | We studied the impact of prenatal androgen exposure on the timing of onset of puberty, maintenance of cyclicity in the first breeding season, and the LH surge mechanism in female sheep. Pregnant sheep were injected with testosterone propionate (100 mg i.m.) twice each week from Day 30 to Day 90 (D30–90) or from Day 60 to Day 90 (D60–90) of gestation (term = 147 days). Concentrations of plasma progesterone and gonadotropins were measured in blood samples collected twice each week from control (n = 10), D60–90 (n = 13), and D30–90 (n = 3) animals. Rate of weight gain and initiation of estrous behavior were also monitored. After the first breeding season, when the animals entered anestrus, competency of the gonadotropin surge system to respond to estradiol positive feedback was tested in the absence or presence of progesterone priming for 12 days. Prenatally androgenized females had similar body weight gain and achieved puberty (start of first progestogenic cycle) at the same time as controls. Durat... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|