P6208VEgetaRian Diet in patients with Ischemic heart disease (VERDI): an open-label, randomized, prospective, cross-over study

Autor:	Yang Cao, C. Särnqvist, Fredrik Bäckhed, F. Carlsson, Rikard Landberg, Ole Fröbert, Demir Djekic, Valentina Tremaroli
Rok vydání:	2019
Předmět:	medicine.medical_specialty business.industry medicine.medical_treatment Percutaneous coronary intervention Disease medicine.disease Crossover study Malnutrition Blood pressure Quality of life Internal medicine Heart rate medicine Cardiology and Cardiovascular Medicine Ischemic heart business
Zdroj:	European Heart Journal. 40
ISSN:	1522-9645 0195-668X
DOI:	10.1093/eurheartj/ehz746.0813
Popis:	Background A vegetarian diet (VD) in patients diagnosed with ischemic heart disease (IHD) may reduce future cardiovascular risk. Purpose The study hypothesis was that patients diagnosed with IHD can benefit from a VD assessed by multiple risk markers for this type of disease. Methods In a crossover study patients diagnosed with IHD, treated by percutaneous coronary intervention and on optimal medical therapy were randomly allocated to a 4-week intervention with ready-made (lunch and dinner) isocaloric VD or meat diet (MD). The primary outcome was change in oxidized low-density lipoprotein cholesterol (LDL-C) levels. Secondary outcomes were difference in changes of blood lipids, weight, body mass index (BMI), blood pressure, heart rate, glycated haemoglobin (HbA1c), number of participants reaching guideline target values, quality of life, gut microbiota, and trimethylamine N-oxide between the two interventions. Results 31 participants were recruited (median age: 67 years, male sex: 93.5%). Significant between-intervention differences (VD vs MD) were found in oxidized LDL-C (−2.73 U/L; p=0.015), total cholesterol (TC) (−0.13 mmol/L, p=0.01), LDL-C (−0.10 mmol/L; p=0.02), weight (−0.67 kg, p=0.008) and BMI (−0.21 kg/m2, p=0.009). After VD, numerically more subjects reached guideline LDL-C target values (87% vs 77%) but this did not reach statistical significance (p=0.07). During VD intervention the diet led to a significant reduction in oxidized LDL-C, TC, LDL-C, HDL-C, ApoB, and ApoB/ApoA1 ratio. Conclusions Our results suggest that in patients with IHD a VD compared to a MD, lowers oxidative stress, improves lipid profile and lowers BMI. Acknowledgement/Funding This study is partially funded by ALF and the Swedish Heart and Lung Foundation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8abddd2670a3bc11a2f15bda0f359dfc https://doi.org/10.1093/eurheartj/ehz746.0813 Zobrazit plný text záznamu