A shortcut hydroformylation route to 7-formyl-5,6-dihydroindolizine from 1-allyl-2-formylpyrrole
| Autor: | Raffaello Lazzaroni, Stefania Savi, Aldo Caiazzo, Roberta Settambolo |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Organic Chemistry chemistry.chemical_element Ring (chemistry) Biochemistry Aldehyde Medicinal chemistry Rhodium Inorganic Chemistry chemistry.chemical_compound chemistry Intramolecular force Materials Chemistry Indolizine Aldol condensation Physical and Theoretical Chemistry Hydroformylation Pyrrole |
| Zdroj: | Journal of Organometallic Chemistry. 619:241-244 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/s0022-328x(00)00658-6 |
| Popis: | When 1-allyl-2-formylpyrrole (1) was subject to hydroformylation conditions with Rh4(CO)12 as catalyst precursor, at 100 atm total pressure and 100°C, 7-formyl-5,6-dihydroindolizine (2′) was produced together with the expected branched aldehyde (3), the linear isomer (2) being obtained in traces only. An intramolecular aldol condensation between the carbon atom adjacent to the formyl group in the chain and the carbonyl group directly bonded to pyrrole ring most likely generates the indolizine structure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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