Inhibition of steroid 5α-reductase by 'inverted', competitive inhibitors
| Autor: | Ian A. McDonald, Cynthia A. Gates, Thomas R. Blohm, Daniel M. Muench, Philip M. Weintruab, Philip L. Nyce, Marie E. Laughlin |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Pharmaceutical Science Reductase Ring (chemistry) Biochemistry Chemical synthesis Steroid chemistry.chemical_compound Enzyme Non-competitive inhibition chemistry Enzyme inhibitor Drug Discovery biology.protein Lactam medicine Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:847-851 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80861-1 |
| Popis: | Modified steroids, in which the D-ring has been converted to a six-membered ring lactam, were designed as inverted (or backward-binding), competitive inhibitors of steroid 5α-reductase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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