Higher Titer Hepatitis B Core Antibody Predicts a Higher Risk of Liver Metastasis and Worse Survival in Patients With Colorectal Cancer
| Autor: | Zi-Yao Li, Hang-Bo Tao, Ke-Min Ni, Jianfeng Gong, Yi-Xiang Zhan, Guo‐xun Li, Shao-Fei Li |
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| Rok vydání: | 2021 |
| Předmět: |
Hepatitis B virus
medicine.medical_specialty Colorectal cancer business.industry virus diseases medicine.disease medicine.disease_cause Gastroenterology digestive system diseases Hepatitis b core antibody Metastasis Titer Surgical oncology Internal medicine medicine Overall survival In patient business |
| Popis: | BACKGROUND There have been controversial voices on if hepatitis B virus infection decreases the risk of colorectal liver metastases or not. This study aims to the find the association between HBV infection and postoperative survival of colorectal cancer and the risk of liver metastases in colorectal cancer patients. METHODS Patients who underwent curative surgical resection for colorectal cancer between January 2011 and December 2012 were included. Patients were grouped according to anti-HBc. Differences in overall survival, time to progress, and hepatic metastasis-free survival between groups and significant predictors were analyzed. RESULTS Three hundred twenty-seven colorectal cancer patients were comprised of 202 anti-HBc negative cases and 125 anti-HBc positive cases, and anti-HBc positive cases were further divided into high-titer anti-HBc group (39) and low-titer anti-HBc group (86). The high-titer anti-HBc group had significantly worse overall survival (5-Yr, 65.45% vs. 80.06%; P < .001), time to progress (5-Yr, 44.26% vs. 84.73%; P < .001), and hepatic metastasis-free survival (5-Yr, 82.44% vs. 94.58%; P = .029) than the low-titer group. Multivariate model showed anti-HBc ≥ 8.8 S/CO was correlated with poor overall survival (HR, 3.510; 95% CI, 1.718-7.17; P < .001), time to progress (HR, 5.747; 95% CI, 2.789-11.842; P < .001), and hepatic metastasis-free survival (HR, 3.754; 95% CI, 1.054-13.369; P = .041) in the anti-HBc positive cases. CONCLUSIONS Higher titer anti-HBc predicts a potential higher risk of liver metastases and a worse survival in anti-HBc positive colorectal cancer patients. |
| Databáze: | OpenAIRE |
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