Ultrasound enhanced delivery of cisplatin loaded nanoparticles
| Autor: | Eleanor Stride, A. H. Harker, Maryam Parhizkar, Richard Browning, Barbara R. Pedley, Mohan Edirisinghe, Shuning Bian, Jonathan C. Knowles, Philip James Thomas Reardon, Daniel F. Daly, Vessela Vassileva |
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| Rok vydání: | 2017 |
| Předmět: |
Cisplatin
Materials science Acoustics and Ultrasonics business.industry Confocal Ultrasound Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Extravasation 0104 chemical sciences PLGA chemistry.chemical_compound Arts and Humanities (miscellaneous) chemistry Microbubbles medicine Particle 0210 nano-technology business Biomedical engineering medicine.drug |
| Zdroj: | The Journal of the Acoustical Society of America. 141:3459-3459 |
| ISSN: | 0001-4966 |
| DOI: | 10.1121/1.4987176 |
| Popis: | Cisplatin forms the basis for many chemotherapy regimens, however the maximum permissible dose is limited by its systemic toxicity. Nanoencapsulation of drugs has been shown to reduce off-target side effects and can potentially improve treatment burden on patients. However, uptake of nanoformulations at tumor sites is minimal without some form of active delivery. We have developed a submicron, polymeric nanoparticle based on biocompatible and degradable poly(lactic-co-glycolic acid) (PLGA) capable of encapsulating cisplatin and which can be bound to the surface of a phospholipid coated microbubble. The acoustic behavior and stability of the resulting nanoparticle loaded microbubbles will be compared with those of unloaded microbubbles. Results will also be presented on the extravasation of particles in a tissue mimicking phantom using a novel long working distance confocal microscope that enables particle distributions to be measured in situ and in real time. |
| Databáze: | OpenAIRE |
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