Features of the reaction of unsymmetrical 2-mercapto-imidazoles with aromatic and aliphatic ketones

Autor:	V. M. Nikitchenko, S. N. Kovalenko, A. V. Borisov, S. G. Dzhavakhishvili
Rok vydání:	2007
Předmět:	chemistry.chemical_compound Oxidative cyclization chemistry Organic Chemistry Aromatic ketones Proton NMR Thiazole X ray analysis Selectivity Medicinal chemistry Combinatorial chemistry
Zdroj:	Chemistry of Heterocyclic Compounds. 43:98-105
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-007-0015-z
Popis:	The cyclization of unsymmetrical 2-mercaptoimidazoles with aliphatic and aromatic ketones has been studied. Using 1H NMR and X-ray analysis it has been shown that 4-R1-1H-2-mercaptoimidazoles undergo selective oxidative cyclization to the corresponding 3-R3-2-R2-6-R1-imidazo[2,1-b][1,3]thiazoles while 6-R4-1H-2-mercaptobenzo[d]imidazoles give a mixture of 6-R4-3-R2-2-R3-benzo[4,5]imidazo[2,1-b][1,3]thiazole and 7-R4-3-R2-2-R3-benzo[4,5]imidazo[2,1-b][1,3]thiazole in the ratio 1: 1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a930482b5b29eecaccee4ffae0afeaa https://doi.org/10.1007/s10593-007-0015-z Zobrazit plný text záznamu Plný text ve formátu PDF