712. High Capacity Screen To Select Optimal Pre-Trans-Splicing Molecules for Trans-Splicing Applications

Autor:	Jun Wang, Yanping Yang, Colette A. Cote, Edward Otto, Lloyd G. Mitchell, Weng Ke, S. Gary Mansfield, Garry P. Nolan, Jonathan E. Spindler, Madaiah Puttaraju
Rok vydání:	2004
Předmět:	Pharmacology Spliceosome Cell Trans-splicing RNA High capacity Computational biology Biology Molecular biology medicine.anatomical_structure Drug Discovery Genetics medicine Molecular Medicine Molecule Molecular imaging Molecular Biology Gene
Zdroj:	Molecular Therapy. 9:S271-S272
ISSN:	1525-0016
DOI:	10.1016/j.ymthe.2004.06.618
Popis:	Spliceosome Mediated RNA Trans-splicing (SMaRT™) is a platform technology to reprogram genes at the pre-mRNA level. Applications include RNA therapy and real-time molecular imaging, with each application dependent upon the nature of the sequences encoded by the pre-trans-splicing molecule (PTM). SMaRT utilizes native spliceosomes to carry out trans-splicing reactions between two RNA molecules: a pre-mRNA target present in the cell and a delivered PTM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a8c34dc74349566085385d303b1f2a4 https://doi.org/10.1016/j.ymthe.2004.06.618 Zobrazit plný text záznamu