| Autor: |
Tanja Trarbach, Arzu Oezcelik, Christopher Sleyman, Eugen Malamutmann, Andreas Paul, Juergen Treckmann, Gernot M. Kaiser, Renate Reinhardt, Georgios C. Sotiropoulos, W. Niebel |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Journal of Surgical Oncology. 105:284-287 |
| ISSN: |
0022-4790 |
| DOI: |
10.1002/jso.22096 |
| Popis: |
Background Esophagectomy with gastric pull-up is the optimal treatment for patients with resectable esophageal cancer. Although the morbidity and mortality of an esophagectomy is reduced, the long-term outcome remains poor. The aim of this study was to evaluate the 10-year survival of a standardized multidisciplinary therapy concept for esophageal cancer. Methods Between 1989 and 1999, 114 patients were treated for esophageal cancer at the University of Essen. All patients underwent an en-bloc esophagectomy with systematic lymphadenectomy. Patients with locally advanced disease (stage III) received neoadjuvant therapy. All patients were followed-up for 10 years or more or until death. Results The 3-year survival was 35%, the 5-year survival 25%, and the 10-year survival was 18%. The recurrence rate was 44% with a median time of 13 months. There was no significant difference in survival between patients with locally advanced disease who received neoadjuvant therapy and patients with early disease (stadium I + II) who underwent surgery alone. Of the patients who achieved 10-year survival, 60% had locally advanced disease and received neoadjuvant therapy. Conclusion Patients with locally advanced disease, managed by a multidisciplinary treatment strategy, achieved a similar long-term survival to patients with early disease (stadium I + II). J. Surg. Oncol. 2012; 105:284–287. © 2011 Wiley Periodicals, Inc. |
| Databáze: |
OpenAIRE |
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