A brainstem-central amygdala circuit underlies defensive responses to learned threats
| Autor: | Gary Aston-Jones, Robert M. Sears, Joseph E. LeDoux, Yiran Gu, Longnian Lin, Elena M. Vazey |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Central nucleus of the amygdala Cell Biology Amygdala 03 medical and health sciences Norepinephrine 0302 clinical medicine medicine.anatomical_structure Lateral nucleus Brain Nucleus medicine Locus coeruleus Brainstem Neuroscience 030217 neurology & neurosurgery 030304 developmental biology medicine.drug |
| DOI: | 10.1101/519249 |
| Popis: | Norepinephrine (NE) plays a central role in the acquisition of aversive learning via actions in the lateral nucleus of the amygdala (LA)1,2. However, the function of NE in expression of aversively-conditioned responses has not been established. Given the role of the central nucleus of the amygdala (CeA) in the expression of such behaviors3, and the presence of NE projections in this brain nucleus, we assessed the effects of NE activity in the CeA on behavioral expression using receptor-specific pharmacology and cell-and projection-specific chemogenetic manipulations. We found that inhibition and activation of locus coeruleus (LC) neurons decreases and increases freezing to aversively conditioned cues, respectively. We then show that locally inhibiting or activating LC terminals in CeA is sufficient to achieve this bidirectional modulation of defensive reactions. These findings support the hypothesis that LC projections to CeA are required for the expression of defensive responses elicited by conditioned threats. |
| Databáze: | OpenAIRE |
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