Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019

Autor:	Elana R Shaw, Lindsey B Rosen, Aristine Cheng, Kerry Dobbs, Ottavia M Delmonte, Elise M N Ferré, Monica M Schmitt, Luisa Imberti, Virginia Quaresima, Michail S Lionakis, Luigi D Notarangelo, Steven M Holland, Helen C Su
Rok vydání:	2021
Předmět:	Microbiology (medical) Infectious Diseases
Zdroj:	Clinical Infectious Diseases. 75:e1192-e1194
ISSN:	1537-6591 1058-4838
DOI:	10.1093/cid/ciab1002
Popis:	Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a74536c40a2eadca2a127e12f3f329f https://doi.org/10.1093/cid/ciab1002 Zobrazit plný text záznamu