Fibrillary Glomerulonephritis in a Patient with Sjogren’s Syndrome
| Autor: | Tahira Sabeen Saleem, Waliul Chowdhury, Aaron R Kuzel, Hafiz Imran Iqbal, Mustafa Rahim, Muhammad Uzair Lodhi, Muhammad Usman |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Past medical history business.industry Fibrillary Glomerulonephritis 030232 urology & nephrology General Engineering Disease 030204 cardiovascular system & hematology medicine.disease Malignancy Dermatology Asymptomatic 03 medical and health sciences 0302 clinical medicine Mesangium Fibromyalgia medicine medicine.symptom business Nephritis |
| Zdroj: | Cureus. |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.2483 |
| Popis: | Fibrillary glomerulonephritis (FGN) is an uncommon cause of primary glomerular disease. FGN is usually idiopathic; however, it has been associated with underlying malignancy or autoimmune diseases in some patients as well. The most commonly found autoimmune diseases in FGN patients include Graves' disease, systemic lupus nephritis, Chron's disease, and idiopathic thrombocytopenia purpura. FGN in a patient with underlying asymptomatic Sjogren's syndrome is very rare in the literature, with only two previously reported cases of this association. We present the case of a 75-year-old female with a past medical history of asymptomatic primary Sjogren's syndrome and fibromyalgia, who presented to emergency department with a new episode of hypertension. The electron microscopy (EM) showed randomly arranged nonamyloid fibrillar deposits in the mesangium and glomerular capillary walls, confirming FGN. In this case-based review, we describe in detail the diagnostic work-up, clinical course, and complications in management. We also discuss some of the other nonamyloid fibrillary glomerular diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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