| Autor: |
K. Petrak, Alain Rolland, S. Sullivan |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Biopharmaceuticals, an Industrial Perspective ISBN: 9789048152377 |
| DOI: |
10.1007/978-94-017-0926-2_20 |
| Popis: |
Gene therapy entails the introduction of a selected gene into a specific somatic cell such that subsequent expression of the gene achieves a therapeutic goal. One of the technical challenges to developing successful gene therapy protocols remains the development of safe and effective gene delivery systems. This chapter focuses upon the many non-viral approaches to achieving target-specific gene delivery. After discussing plasmid-based gene medicines and their manufacture, lipid-, polymer- and polypeptide-based gene delivery systems are presented in detail. A selected review of clinical trials undertaken using non-viral delivery systems is then presented. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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