Shedding of Culturable Virus, Seroconversion, and 6-Month Follow-up Antibody Responses in the First 14 Confirmed Cases of Coronavirus Disease 2019 in the United States
| Autor: | Xiaoyan Lu, Hannah L Kirking, John T. Watson, Aron J. Hall, Melisa M Shah, Phillip P. Salvatore, Jeremy A W Gold, Brett Whitaker, Glen R. Abedi, Susan I. Gerber, Mohammad Ata Ur Rasheed, Jennifer L Harcourt, Marie E Killerby, Stephen Lindstrom, Melissa M. Coughlin, Stephanie A Kujawski, Alicia M. Fry, Jacqueline E. Tate, Claire M Midgley, Azaibi Tamin, Natalie J. Thornburg |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | The Journal of Infectious Diseases. 224:771-776 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiab125 |
| Popis: | We aimed to characterize presence of culturable virus in clinical specimens during acute illness, and antibody kinetics up to 6 months after symptom onset, among 14 early patients with coronavirus disease 2019 in the United States. We isolated viable severe acute respiratory syndrome coronavirus 2 from real-time reverse-transcription polymerase chain reaction–positive respiratory specimens collected during days 0–8 after onset, but not after. All 13 patients with 2 or more serum specimens developed anti-spike antibodies; 12 developed detectable neutralizing antibodies. We did not isolate virus after detection of neutralizing antibodies. Eight participants provided serum at 6 months after onset; all retained detectable anti-spike immunoglobulin G, and half had detectable neutralizing antibodies. Two participants reported not feeling fully recovered at 6 months. |
| Databáze: | OpenAIRE |
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