The Antiangiogenic and Antinociceptive Activities of n-Propyl Gallate

Autor:	Lim Cj, Jung Hj
Rok vydání:	2011
Předmět:	Pharmacology Stereochemistry business.industry Angiogenesis macromolecular substances Gallate Umbilical vein law.invention Chorioallantoic membrane chemistry.chemical_compound Downregulation and upregulation chemistry law cardiovascular system Medicine heterocyclic compounds Endostatin business Phytotherapy Propyl gallate
Zdroj:	Phytotherapy Research. 25:1570-1573
ISSN:	0951-418X
DOI:	10.1002/ptr.3452
Popis:	n-Propyl gallate dose-dependently displayed an inhibitory effect on chick chorioallantoic membrane (CAM) angiogenesis. It markedly increased the endostatin level in both isolated CAM tissues and human umbilical vein endothelial cells (HUVECs). n-Propyl gallate was also able to enhance the endostatin mRNA level in HUVECs. Antinociceptive activity of n-propyl gallate was assessed using an acetic acid-induced writhing test in mice. In brief, n-propyl gallate possesses antiangiogenic activity via up-regulation of endostatin.
Databáze:	OpenAIRE
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