Entrapment of collagen on polylactic acid 3D scaffold surface as a potential artificial bone replacement
| Autor: | Nadirul Hasraf Mat Nayan, Saiful Izwan Abd Razak, Mohd Syahir Anwar Hamzah, Celine Ng, Nur Ismalis Shafeqa Zulkarnain, Huda A. Majid |
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| Rok vydání: | 2021 |
| Předmět: |
010302 applied physics
Scaffold Artificial bone Materials science Simulated body fluid technology industry and agriculture macromolecular substances 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Contact angle chemistry.chemical_compound Polylactic acid chemistry 0103 physical sciences medicine Fourier transform infrared spectroscopy Swelling medicine.symptom 0210 nano-technology Biomedical engineering Biomineralization |
| Zdroj: | Materials Today: Proceedings. 46:1668-1673 |
| ISSN: | 2214-7853 |
| Popis: | A new potential biomimetic polymeric 3D scaffold is fabricated using collagen entrapment and 3D printed polylactic acid scaffold. The modified scaffold was characterized by compressive modulus, degree of swelling, water contact angle (WCA), and Fourier Transform Infrared Spectroscopy (FTIR). The findings show that sample PLA/col40 with 40 s entrapment duration is the optimum composition that meets the requirement for artificial bone tissue replacement. In vitro biomineralization using simulated body fluid (SBF) demonstrates that the PLA/collagen 3D scaffold is able to promote the growth of hydroxyapatite (HA) after 7 days which will subsequently improve the osteoconductive and osteoinductive properties of the 3D scaffold. The overall results suggest the potential of the 3D PLA/collagen scaffold as a prospective material for bone tissue engineering applications. |
| Databáze: | OpenAIRE |
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