| Autor: |
Mohammed F. Islam, Ben Z. Katz, Jacob D. Furst, Leonard A. Jason, Joseph Cotler |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3821486 |
| Popis: |
Background : Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness affecting over a million people in the US. About 9-12% of individuals develop this syndrome six months following Infectious Mononucleosis (IM); those who meet > 1 set of criteria for ME/CFS are termed severe ME/CFS. We sought to determine why some individuals develop ME/CFS following IM while most recover. Methods: Our study was a prospective cohort study conducted at Northwestern University. We recruited a cohort of college students before, during, and after being infected with IM. Those who developed IM were followed-up with at six months to determine whether they recovered or met criteria for ME/CFS. We explored baseline levels and severity at follow-up of IM variables for those who recovered from IM and those who developed severe ME/CFS 6 months following IM. Findings: Pre-illness variables that differentiated these groups included baseline gastrointestinal symptoms and certain cytokines. At onset of IM, gastrointestinal symptoms differentiated the two groups. Interpretation: The differences that emerged predicted the onset of severe ME/CFS following IM. Our research has thus uncovered risk factors predisposing to non-recovery following IM so that preventative and treatment strategies for ME/CFS may now be devised and studied. Funding: This work was supported by the National Institute of Allergy and Infectious Diseases [grant number AI 105781]. Declaration of Interest: The authors declare no competing interests. Ethical Approval: Institutional Review Board approval was obtained. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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