Osteoarthritic synovial fluid and correlations with protein concentration
| Autor: | Anwar Madkhali, Samin Fakhraei, Dana Grecov, Michael Chernos, Ezra Kwok |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
Materials science Physiology Capillary action Rheometer 0206 medical engineering Relaxation (NMR) 02 engineering and technology Mechanics Breakup 020601 biomedical engineering Shear (sheet metal) 03 medical and health sciences 0302 clinical medicine Rheology Physiology (medical) Synovial fluid Extensional viscosity |
| Zdroj: | Biorheology. 53:123-136 |
| ISSN: | 1878-5034 0006-355X |
| DOI: | 10.3233/bir-15086 |
| Popis: | Background Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. The effects of osteoarthritis on the extensional rheology of synovial fluid in the knees are not fully understood and consequently require further study. Objective The purpose of this work is to study the extensional rheology of osteoarthritic synovial fluid and to investigate a possible correlation between synovial fluid protein concentration and extensional rheology. The study will also investigate possible correlations with the shear rheology. Methods 21 osteoarthritic synovial fluid samples were studied under extensional flow with a capillary breakup extensional rheometer. Extensional rheological properties were correlated with protein concentration and with shear rheological properties measured in a prior study. Viscosupplement was also studied under extensional flow for comparison. Results Extensional rheological properties were found to vary widely between samples, but in general were found to agree with previous studies. No statistically significant correlation was identified between extensional rheological properties and protein concentration. Positive correlations were identified between zero shear viscosity and terminal extensional viscosity (R-squared = 0.73), zero shear viscosity and extensional relaxation time (R-squared = 0.84), and shear relaxation time and extensional relaxation time (R-squared = 0.75). Conclusions Appropriate CaBER operating parameters for study of osteoarthritic synovial fluid were identified. No statistically significant correlation was found to exist between protein concentration and extensional rheological parameters. Positive correlations were identified between several shear and extensional rheological parameters. The reported values for extensional viscosity and relaxation times for synovial fluid were found to be within one order of magnitude with a recent study of post mortem synovial fluid. |
| Databáze: | OpenAIRE |
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