ChemInform Abstract: CYP3A4 Inhibitory Activity of New Bisalkaloids, Dipiperamides D and E, and Cognates from White Pepper

Autor:	T. Abe, Sachiko Tsukamoto, Bae Cheon Cha, Hiroshi Hirota, Keiko Miyakawa, Toshiyuki Hamada, Kyoko Tomise, Tomihisa Ohta
Rok vydání:	2010
Předmět:	Piper CYP3A4 biology Chemistry food and beverages Cytochrome P450 General Medicine Inhibitory postsynaptic potential biology.organism_classification White (mutation) Drug metabolizing enzymes Biochemistry Pepper Ic50 values biology.protein
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200249177
Popis:	Two new bisalkaloids, dipiperamides D and E, were isolated as inhibitors of a drug metabolizing enzyme cytochrome P450 (CYP) 3A4 from the white pepper, Piper nigrum. Their structures were elucidated by spectroscopic methods. Dipiperamides D and E showed potent CYP3A4 inhibition with IC50 values of 0.79 and 0.12 μM, respectively, and other metabolites from the pepper were moderately active or inactive.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a5c36bb26db37695d4a75be2574bb15 https://doi.org/10.1002/chin.200249177 Zobrazit plný text záznamu Plný text