Regio- and diastereoselective dialkylation of (4S)-2,4-dimethyl-2,4-dihydro-1H-pirazino[2,1-b]quinazoline-3,6-dione

Autor:	Carmen Avendaño, Modesta Espada, Sonsoles Martín-Santamaría
Rok vydání:	1997
Předmět:	chemistry.chemical_compound DMPU chemistry Stereochemistry Organic Chemistry Drug Discovery Urea Quinazoline Alkylation Biochemistry Asymmetric induction Stereocenter
Zdroj:	Tetrahedron. 53:16795-16802
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(97)10082-5
Popis:	Dialkylation of the title compound occurs regioselectively at C-1. Addition of N,N′-dimethyl-N,N′-propylene urea (DMPU) permits the one-pot synthesis of 1,1-dialkylation products in good yields. The asymmetric induction of the stereogenic C-4 center directs the first and the second alkylation steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a59ee8f2a2a21f80f083a618d9c6538 https://doi.org/10.1016/s0040-4020(97)10082-5 Zobrazit plný text záznamu Full Text from ScienceDirect