Protective Effect of Spirodela polyrhiza on Various Organs of Arsenicinduced Wistar Albino Rats
| Autor: | Salma Chowdhury Du, Rasheda Akter, Mohammad Al-Forkan, Zillur Rahman, Santosh Mazumdar, Faridul Islam, Saiful Islam, Laila Khaleda |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Kidney Necrosis Sodium arsenite 030102 biochemistry & molecular biology biology Sodium chemistry.chemical_element Histology 010501 environmental sciences Pharmacology biology.organism_classification 01 natural sciences Toxicology 03 medical and health sciences chemistry.chemical_compound Spirodela polyrhiza medicine.anatomical_structure chemistry Toxicity medicine medicine.symptom Arsenic 0105 earth and related environmental sciences |
| Zdroj: | Journal of Cytology & Histology. |
| ISSN: | 2157-7099 |
| DOI: | 10.4172/2157-7099.1000410 |
| Popis: | Our study was undertaken to assess the protective effect of Spirodela polyrhiza against sodium arseniteinduced toxicity in experimental model. Animals were divided into six groups. The first group was used as control group while the other groups were treated with S. polyrhiza, sodium arsenite (10 ppm), 10 ppm As plus S. polyrhiza, sodium arsenite (30 ppm), and 30 ppm As plus S. polyrhiza respectively. Organs (kidney, spleen and heart) were collected at the end of the experiment for conducting histopathological analysis and measuring the amount of deposited arsenic. Tubular epithelium necrosis was seen affecting less than 50% of all renal specimens, on the other hand slightly enlarged white pulp region in splenic tissue were found in the groups of Wistar rat where S. polyrhiza and arsenic was administered concomitantly. Moreover, the observed moderate tissue changes (edema and muscle necrosis) in cardiac specimens of arsenic treated groups were found to be mild in the S. polyrhiza +arsenic treated groups. It is noteworthy to mention that S. polyrhiza not only reversed the arsenic-induced toxicity but also reduced the tissue arsenic load in Wistar rats to a considerable extent. Overall, the results indicated that S. polyrhiza might become useful in mitigating the toxic effects of arsenic. |
| Databáze: | OpenAIRE |
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