ChemInform Abstract: New Methodology for the Preparation of 3-Hydroxy-2-pyridinone (3,2-HOPO) Chelators - Reaction of Amines with a Novel Electrophilic 3,2-HOPO Precursor

Autor:	Aravamudan S. Gopalan, Hollie K. Jacobs, Sumathi Chittamuru, Timothy N. Lambert
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Aqueous solution Aniline chemistry Ligand Electrophile Salt (chemistry) Peptide bond Iminium Amine gas treating General Medicine Combinatorial chemistry
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200252132
Popis:	The preparation of the new electrophilic iminium ester mesylate salt 5 and its reaction with primary and secondary amines have been investigated. Aniline, t-butylamine, and secondary amines react with 5 via ring opening to give the corresponding HOPO derivatives in high yields. The usefulness of this methodology has been demonstrated by the preparation of two new di-HOPO derivatives 19 and 21. This method allows the introduction of the HOPO ligand onto a variety of amine platforms without the concomitant formation of an amide bond and provides access to HOPO chelators of increased water solubility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a534461d9e6dcd81a1fb436dea83f11 https://doi.org/10.1002/chin.200252132 Zobrazit plný text záznamu Plný text