Shellac-polyamidoamine: Design of a new polymeric carrier material for controlled release application
| Autor: | Tanushree Patnaik, G. S. Tiwary, Usha Jha, R. K. Dey |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics Scanning electron microscope Kinetics General Chemistry Polymer Biodegradable polymer Controlled release Buffer (optical fiber) Surfaces Coatings and Films Photopolymer Chemical engineering chemistry visual_art Polymer chemistry Shellac Materials Chemistry visual_art.visual_art_medium |
| Zdroj: | Journal of Applied Polymer Science. 125:2626-2635 |
| ISSN: | 0021-8995 |
| DOI: | 10.1002/app.36411 |
| Popis: | The development of a pH sensitive, biodegradable polymer from the combination of Shellac (a natural polymer secreted by lac insect) and polyamidoamine (PAA) (a synthetic polymer) yielded a new biocompatible polymer Shellac-PAA in a photopolymerization process. Scanning electron micrograph of Shellac-PAA shows an interesting heterogeneous surface morphology supported with observation of two different melting temperatures obtained from differential scanning calorimetric measurement. The equilibrium swelling properties of the polymeric material was studied as a function of pH and time in buffer solutions similar to that of gastric and intestinal fluids. The controlled release kinetics of a model colon specific drug 5-aminosalicylic acid showed Fickian diffusion behavior. The new polymer is biocompatible, biodegradable and, hence, projected as a new kind of polymer with improved properties, which can be a potential candidate for controlled release of therapeutic agents in colon specific diseases. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 |
| Databáze: | OpenAIRE |
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