Synthesis and evaluation of antitumor activity of a homologous series of 1-(ω-cyanoalkyl)-and 1,3-bis (ω-cyanoalkyl)uracil nucleoside analogues

Autor:	Seon Hee Kim, Jack C. Kim, Jun-Won Ahn, Eun-Soo Dong
Rok vydání:	1994
Předmět:	Nitrile Chemistry Stereochemistry Organic Chemistry Cell Uracil Alkylation chemistry.chemical_compound Homologous series medicine.anatomical_structure Column chromatography Cell culture Drug Discovery medicine Molecular Medicine Uracil nucleoside
Zdroj:	Archives of Pharmacal Research. 17:135-138
ISSN:	1976-3786 0253-6269
DOI:	10.1007/bf02974247
Popis:	Acyclonucleoside homologues of 1-(ω-cyanoalkyl)-and 1,3-bis (ω-cyanoalkyl) uracils were synthesized by the series of alkylation reactions of uracil with the ω-chloroalkyl nitrile (Cl-(CH2)n-CN; n=1, 2, 3, 4) in DMSO under 50∼75°C temperature. The 1-(ω-cyanoalkyl)-and 1,3-bis(ω-cyanoalkyl) uracils were separated either by the fractional crystallization or column chromatography. The antitumor activities for these synthesized compounds were determined against four cell lines (J-82 cell, P388 cell, FM-3A cell and U-937 cell lines). These compounds failed to exhibit any significant antitumor activity.
Databáze:	OpenAIRE
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