| Popis: |
A copper-catalyzed formal allylboration of terminal alkynes using allyl bromides or sulfonates as electrophiles has been achieved. This method exhibits good regio-/stereoselectivity and good functional group tolerance for various substituents on the aromatic rings of arylethynes. Through this strategy, various arylsubstituted trisubstituted vinyl pinacol boronic esters with 1,4-diene skeleton have been constructed. In order to demonstrate the utility of this method, the resulting 1,4-dienes with boron-substitution were applied to further transformations such as Suzuki coupling, oxidation, halogenation, and so on, leading to various important compounds. |
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