| Autor: |
H. Herbots, Christine L. Provost, Renaat Kinget |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutics. 62:217-228 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/0378-5173(90)90235-v |
| Popis: |
The elements controlling the formation of transparent oil-water gels in a four-component system were investigated by means of differential scanning calorimetry. The model system had two emulsifying agents, CetiolR HE and EumulginR B3, an oily liquid, isopropyl palmitate, and water. The thermal behaviour of the single components and of some of their binary emulsifier-water and ternary emulsifier-oil-water mixtures was also studied. The results showed that the mechanism underlying the formation of transparent oil-water gels involved an interaction of isopropyl palmitate with one or both hydrated emulsifiers. Not only the behaviour of the emulsifiers in water but also the melting behaviour of isopropyl palmitate and the melting of the gel were clearly affected by the oil content of the gel. An increase in structural organisation can be inferred from the evolution of the melting point of the gel with increasing isopropyl palmitate concentrations. The binding forces responsible for the gel structure seem to be hydrogen bonds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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