Circulating apoptotic and necrotic cell death markers in patients with acute liver injury
| Autor: | Peter C. Hayes, Kenneth J. Simpson, G. Masterton, Patricia Lee, E. A. Pryde, Darren G. Craig |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Liver injury
medicine.medical_specialty Programmed cell death Necrosis Hepatology biology business.industry medicine.medical_treatment Liver transplantation HMGB1 medicine.disease Chronic liver disease Gastroenterology Acetaminophen Apoptosis Internal medicine Immunology medicine biology.protein medicine.symptom business medicine.drug |
| Zdroj: | Liver International. 31:1127-1136 |
| ISSN: | 1478-3223 |
| DOI: | 10.1111/j.1478-3231.2011.02528.x |
| Popis: | Background: The host response to cell death underpins the immune activation that follows acute liver injury, and measurement of circulating cell death markers could therefore aid prognostication following paracetamol overdose. Nucleosomes, formed during apoptosis, can complex with high-mobility group box 1 (HMGB1) protein and may play a pathogenic role in liver injury. Aims: To explore the levels and prognostic significance of nucleosomes, HMGB1, and other cell death markers following acute liver injury. Methods: Levels of plasma nucleosomes, HMGB1, caspase-cleaved cytokeratin-18 (M30) and total cytokeratin-18 (M65) were measured by immunoassay, in a cohort of 33 patients with paracetamol- and non-paracetamol-induced acute liver injury. Results: Admission nucleosome levels in paracetamol overdose patients were significantly higher than in chronic liver disease and healthy control subjects, but were similar in paracetamol and non-paracetamol patients (P=0.11). Nucleosome levels were not associated with death or requirement for liver transplantation, fulfillment of poor prognostic criteria or organ failure in paracetamol patients. Nucleosome levels correlated with levels of HMGB1 (r=0.500, P=0.009), alanine aminotransferase (r=0.410, P=0.038) and M65 (r=0.709, P |
| Databáze: | OpenAIRE |
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