Antibacterial activity of Ampicillin trihydrate formulated in Aluminium-Magnesium Silicate, against Salmonella gallinarum

Autor:	Okechi K. Okorie, GN Anosa, A. A. Ngene, Ogechukwu N. Chikelu, Nnenna P. Elendu-Eleke, Maduike C. O. Ezeibe, O. N. Okoroafor
Rok vydání:	2012
Předmět:	Mean diameter Inhibition zone Sensitivity test chemistry Magnesium silicate Aluminium chemistry.chemical_element Ampicillin Trihydrate Salmonella Gallinarum Antibacterial activity Nuclear chemistry Microbiology
Zdroj:	Health. :675-678
ISSN:	1949-5005 1949-4998
Popis:	To test if stabilizing Ampicillin trihydrate (AT) with Aluminium-Magnesium Silicate (AMS) can enhance its antibacterial activities, different concentrations of AT solution and of a formulation of AT in the AMS, were made and used for sensitivity test on Salmonella gallinarum cultures. Also, S. gallinarum-infected chicks were treated with; 10 mg/Kg (AT), 10 mg/Kg (AT in AMS), 7.5 mg/Kg (AT), 7.5 mg/Kg (AT in AMS). Mean diameter of inhibition zone, 28.39 ± 2.07 mm produced by AT did not vary significantly (P > 0.05) from 26.36 ± 2.05 mm produced by AT in AMS. However, mean Salmonella gallinarum culture forming units per ml of bile, 17.6 ± 11 × 105of the untreated chicks and 3.4 ± 0.81 × 105(80.58% reduction), 2.4 ± 0.67 × 105(85.70% reduction), 5.4 ± 1.93 × 105(69.20% reduction ) and 0.38 ± 0.13 × 105(97.80% reduction ) of the respective treated groups, showed AMS significantly (P S. gallinarum infection, in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a2333047f49923e1588fd22f1da566d https://doi.org/10.4236/health.2012.49106 Zobrazit plný text záznamu