Tu2042 A Multi-Centre, Randomised, Double-Blind, Controlled Trial Determining the Effect of Additional Fructo-Oligosaccharides on Fecal Microbiota and Short-Chain Fatty Acids Among Critical Care Patients Receiving Enteral Nutrition
| Autor: | Clare Reid, Tony Sherry, Peter W. Emery, Richard Beale, Kevin Whelan, Hazreen B. Abdul Majid, J. Cole, Max Ervine |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Intestinal permeability Hepatology business.industry Gastroenterology Inflammation medicine.disease chemistry.chemical_compound Insulin resistance Parenteral nutrition chemistry Internal medicine Genetic model Medicine Colitis medicine.symptom business Sirius Red Dyslipidemia |
| Zdroj: | Gastroenterology. 142:S-909 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/s0016-5085(12)63529-x |
| Popis: | Background. Intestinal inflammation is increasingly recognized to support metabolic dysfunction in distant tissues including liver and cardiovascular system. The intestinal microbiota is essential in instructing the systemic immune system and its modulation is recognized to be an important target for treating systemic disorders. Aim. To investigate the effect of administration of VSL#3 in ApoE-/mice challenged with low doses of DSS. Material and methods. Intestinal inflammation was induced by 3-moths administration of 0.2% DSS in drinking water to ApoE-/mice. Mice were randomized to receive vehicle or VSL#3, daily, at the dose of 20 X 109 colony-forming units/kg/day, for 3 months. Results. Administering DSS to ApoE-/mice failed to induce signs and symptoms of colitis (the diarrhea score rose to 1.5) but increased intestinal permeability to dextrane FITC and, while had no effect on serum cholesterol and triglyceride levels, caused a 2-folds increase of AST and ALT levels (p |
| Databáze: | OpenAIRE |
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