Systemic Inflammation and Cognitive Decrements in Patients With Stage B Heart Failure
| Autor: | Laura S Redwine, Barry E. Hurwitz, Jordan Kohn, Kathleen Wilson, Claudia Martinez, Barry H. Greenberg, Suzi Hong, Meredith A. Pung, Paul J. Mills, Christopher Pruitt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class Montreal Cognitive Assessment Cognition Odds ratio Disease Systemic inflammation medicine.disease Gastroenterology Psychiatry and Mental health Internal medicine Heart failure medicine Natriuretic peptide medicine.symptom business Body mass index Applied Psychology |
| Zdroj: | Psychosomatic Medicine. 84:133-140 |
| ISSN: | 1534-7796 0033-3174 |
| DOI: | 10.1097/psy.0000000000001033 |
| Popis: | OBJECTIVE To investigate the role of systemic inflammation in reduced cognitive functioning in patients with early-stage heart failure (HF), while taking associations with other cardiovascular risk factors into account. METHODS Patients with stage B HF (n = 270; mean age 66.1 ± 10.1) were examined cross-sectionally for relationships among cardiovascular disease (CVD) and psychological risk factors, c-reactive protein (CRP) and Montreal Cognitive Assessment (MoCA) scores. A subsample (n = 83), at high-risk for stage C HF (B-type natriuretic peptide (BNP) levels >65 pg/mL) were followed for 12-months for relationships between CRP levels and cognitive function. RESULTS Baseline smoking (c2 = 6.33), unmarried (c2 = 12.0), hypertension (c2 = 5.72), greater body mass index (d = .45), and physical fatigue (d = .25) were related to higher CRP levels (p's < .05). Cross-sectionally, CRP levels were negatively related to MoCA scores, beyond CVD (DR2 = .022, b = -.170, p < .010) and psychological risk factors (DR2 = .016, b = .145, p < .027) and related to MCI criteria (odds ratio = 1.35, 95% CI 1.00 - 1.81, p = .046). Across 12-months, BNP high-risk patients with CRP levels ≥3 mg/L had lower MoCA scores (23.6; 95% CI 22.4 - 24.8) than patients with CRP levels |
| Databáze: | OpenAIRE |
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