Histochemical demonstration of terminal deoxynucleotidyl transferase in leukemia
| Autor: | Sally Santos, Karl J. Winkler, William Z. Borer, Fumiko Carlson, Stephen J. Forman, Thomas Hecht, Karl G. Blume, William C. Maslow, Ursula S. Winkler |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
chemistry.chemical_classification
Indirect immunofluorescence business.industry Immunology Cell Biology Hematology medicine.disease Biochemistry Molecular biology Lymphoma Leukemia Enzyme chemistry Terminal deoxynucleotidyl transferase hemic and lymphatic diseases Acute lymphocytic leukemia Cancer research medicine CD5 business Chronic myelogenous leukemia |
| Zdroj: | Blood. 58:856-858 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v58.4.856.856 |
| Popis: | White blood cells from 22 patients with leukemia and lymphoma were studied for the presence of terminal deoxynucleotidyl transferase with a peroxidase-antiperoxidase method. The enzyme was detected in leukemic cells of 5 patients with acute lymphoblastic leukemia and 1 patient with chronic myelogenous leukemia, whereas 16 patients with different forms of leukemia or lymphoma were negative for this enzyme. Comparative studies using a biochemical and an indirect immunofluorescence assay revealed complete concordance between these three methods. |
| Databáze: | OpenAIRE |
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