Effect of Added Cu(OTf)2 on the Cu(OTf)2(Py)4-Mediated Radiofluorination of Benzoyl and Phthaloylglycinates

Autor:	Murthy R. Akula, George W. Kabalka, Dustin Osborne, David W. Blevins
Rok vydání:	2018
Předmět:	Copper complex 010405 organic chemistry Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences
Zdroj:	Natural Science. 10:125-133
ISSN:	2150-4105 2150-4091
Popis:	Cu(OTf)2(Py)4 mediated radiofluorination of the boronate esters of ethyl benzoyl and phthaloylglycinates (11 and 16) using 10 mol% of the copper complex following the literature procedure did not provide the fluorinated products. However, the addition of Cu(OTf)2resulted in the radio-fluorination of the boronate esters 11 and 16 to obtain ethyl 4-[18F]fluorobenzoyl glycinate, 17, (48%) and ethyl 3-[18F]phthaloylglycinate (41%) respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a18d83f61dd7796db11759a1eac78a5 https://doi.org/10.4236/ns.2018.103013 Zobrazit plný text záznamu