Purine-enriched asanguineous cardioplegia retards adenosine triphosphate degradation during ischemia and improves postischemic ventricular function
| Autor: | Robert M. Mentzer, Robert D. Lasley, Berne Rm, Richard D. Mainwaring, Walsh R, Stephen W Ely, David A. Wyatt |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pulmonary and Respiratory Medicine
Purine medicine.medical_specialty Ischemia Pharmacology law.invention chemistry.chemical_compound law Internal medicine Cardiopulmonary bypass Medicine Hypoxanthine biology business.industry Fissipedia Metabolism biology.organism_classification medicine.disease Adenosine Endocrinology chemistry Surgery Cardiology and Cardiovascular Medicine business Adenosine triphosphate medicine.drug |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 97:771-778 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(19)34523-4 |
| Popis: | Myocardial dysfunction after induced ischemic arrest is an important problem in cardiac surgery. Adenosine-5’-triphosphate content in myocardial tissue remains depressed for days after ischemia, perhaps because of reperfusion washout of diffusable purine substrates. Left ventricular function is also depressed after ischemia, but its relationship to absolute tissue adenosine triphosphate content is unclear. We tested the hypothesis that arresting hearts with a cardioplegic solution containing adenosine, hypoxanthine, and ribose would result in improved tissue adenosine triphosphate content and left ventricular function after 1 hour of normothermic global ischemia in dogs supported by cardiopulmonary bypass. Animals with ischemic arrest initiated with a crystalloid cardioplegic solution containing adenosine 100 μmol/L, hypoxanthine 100 μmol/L, and ribose 2 mmol/L demonstrated significant improvement (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|